Mariah campaigns to turn the city and the police against Luke, and not even Misty or Claire may be able to save him.
Cottonmouth strikes back at Luke by taking his vengeance out on the people of Harlem, while detectives Knight and Scarfe face an unexpected threat.
With tension building in the streets of Harlem thanks to ruthless club owner Cottonmouth, Luke finds it increasingly difficult to live a quiet life.
Red and the FBI try to stop a dangerous messenger (Robert Knepper) whose appearance is unknown; Liz is thrust into a kidnapping plot.